WebOct 6, 2024 · Patients were randomly assigned to 5 mg olanzapine or placebo; all of them received triple antiemetic therapy with 5-HT3 receptor antagonist, NK-1 receptor antagonist, and dexamethasone. The study aimed to assess the antiemetic effect when 5 mg olanzapine was added to the triple therapy. WebVarious Antiemetic Agents 5-Hydroxytryptamine (5-HT3) receptor antagonists As serotonin plays an integral role in the pathophysiology of CINV, 5-HT3 RAs (ondansetron, granisetron, dolasetron, and palonosetron) are invaluable antiemetic agents in the management landscape of CINV ( 39 ).
Concomitant palonosetron ameliorates cisplatin-induced …
WebJan 1, 2024 · In this study, we evaluated the efficacy of olanzapine combined with triple antiemetic therapy for the prevention of CINV in patients receiving multiday chemotherapy. Methods. We performed a randomized, double-blind, placebo-controlled phase 3 trial in 22 hospitals. Eligible patients were between 18 and 75 years old, were diagnosed with ... WebDec 7, 2016 · Triple therapy comprising palonosetron, aprepitant and dexamethasone seems to be the strongest antiemetic treatment. Miura et al. ( 2013) reported on the efficacy of triple treatment for CINV in lung-cancer patients receiving HEC. Prevalence of a CR and CC overall was 81.1 and 66.7%, respectively, and treatment carried a good safety profile. tauhu basah
Efficacy of triplet regimen antiemetic therapy for …
WebDec 23, 2014 · The first aim of this study was to evaluate combination antiemetic therapy consisting of 5-HT 3 receptor antagonists, neurokinin-1 receptor antagonists (NK-1RAs), and dexamethasone for multiple high emetogenic risk (HER) anticancer agents in bone and soft tissue sarcoma. The second aim was to compare the effectiveness of single-shot … WebFor high emetic risk regimens, triple antiemetic therapy using aprepitant (a NK-1 receptor antagonist), 5-HT3 antagonist, and dexamethasone is recommended. ... Inui N. Antiemetic therapy for non-anthracycline and cyclophosphamide moderately emetogenic chemotherapy. Med Oncol 2024;34:77. WebAntiemetic prophylaxis guidelines for HEC and AC-based chemotherapy recommend the use of a triple combination of NK1-RA, a 5-HT3-RA, and dexamethasone. Because of the use of different drugs on days following chemotherapy, patients with cancer need to take antiemetic drugs at home, increasing the risk of lack of compliance. 26,35,36 tau huay singapore recipe