Human aggrecan gene
WebBiomechanical cues arise from cellular interactions with their surrounding matrix and from applied forces. This study investigates the role of biomechanical cues in chondrogenic and osteogenic differentiation of human marrow stromal cells (hMSC) when encapsulated in synthetic hydrogels. WebIn this study, we prepare a decellularized human nasal septal chondrocyte (NSC)-derived ECM (CHDM), as a natural (N-CHDM) or soluble form (S-CHDM), and investigate their impact on NSCs differentiation. Methods: N-CHDM, S-CHDM were obtained from NSC. To evaluate function of NSC cultured on each substrate, gene expression using …
Human aggrecan gene
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WebACAN gene aggrecan Normal Function The ACAN gene provides instructions for making the aggrecan protein. Aggrecan is a type of protein known as a proteoglycan, which … WebFurther, histopathologic and Western blot studies of diabetic mice knee joints revealed enhanced carboxymethyl lysine (advanced glycation end product), matrix metalloproteinase-1, and reduced cartilage-specific proteins, including type II collagen (Col II), SOX9, and aggrecan (AGN), indicating deteriorated articular cartilage and proteoglycans.
WebThis gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands … WebVersican (VCAN) is a large extracellular matrix proteoglycan that is expressed in majority human tissues. VCAN is localized on human chromosome 5q14.3, covering a genomic sequence of 109.4 kb. 8 VCAN cDNA contains 15 exons and codes a protein with a molecular mass of >1000 kDa, which belongs to the aggrecan/versican proteoglycan …
Web10 Apr 2024 · The expression of collagen type II, p-ERK, and aggrecan was also downregulated, and the expression of collagen type X was upregulated in the articular cartilage of these mice. Our findings suggest that DYRK1A delays the progression of knee osteoarthritis in mice, at least in part, by maintaining EGFR-ERK signaling in articular … Web28 Oct 2024 · Aggrecan protein structure is shown in the bottom row with crucial domains. The variants detected in Chinese patients are highlighted in red, among which variants …
WebTo further investigate the regulation role of two chemokine genes CCL3 and CCL4 in chondrocytes in response to resistin, human primary chondrocytes and T/C-28a2 cells were cultured. The function of resistin on the chemokine genes, and the expression of C/EBPβ, NF-κB isoforms were tested using qPCR. The methods used to investigate timed co …
Webaggrecan Synonyms: AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK Species: Human ACAN (176), Mouse Acan (11595), Rat Acan (58968), chicken... Summary: This gene is a member of the aggrecan/versican proteoglycan family.... Related Products: Antibodies miRNA Mimics Proteins esiRNA shRNA siRNA See All Related Genes All Photos ( 1) raytown pump trackWebIn 1999, two members of the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of metalloproteinases, ADAMTS4 and ADAMTS5, or aggrecanases, were identified as the... simply organic chicken tendersWebHuman Aggrecan, amino acids (Val20-Gly675) (Accession# NP_001126), was expressed in 293E cells with a C-terminal 10 His tag and a linker sequence. Molecular Mass This 672 amino acid recombinant protein with a C-terminal His tag has a predicted molecular mass of approximately 74.3 kD. simply organic chips krogerWebThe large chondroitin sulphated proteoglycan aggrecan (ACAN) is and most plenty non-collagenous protein in cartilage and is essential for its structure also function. Mutations inside ACAN result within a broad phenotypic rainbow of non-lethal skeletal dysplasias contains spondyloepimetaphyseal dysplasia, spondyloepiphyseal dysplasia, familial … raytown public schools calendarWeb25 Dec 2015 · ment in collagen scaffolds enhanced the gene expression of aggrecan, indicating cell responsiveness to anisotropy that also better replicates the natural environment of cartilage. Finally, the ... simply organic chili limeWeb1 Sep 2024 · This literature review leads us to conclude that aggrecan is likely to participate in cardiovascular development, with definitive data from different vertebrates (zebrafish, … raytown post office 64133WebVersican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.. Versican is a large chondroitin sulfate … simply organic chives