2024 Growth arrest specific 6

Growth arrest specific 6

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August undefined, 2024

WebJul 13, 2013 · Currently, seventeen members of the Gla protein family are known, including seven proteins involved in blood coagulation (all synthesised in the liver), osteocalcin (OC; bone), matrix Gla protein (MGP; mainly cartilage and vessel wall), growth arrest-specific protein 6, Gla-rich proteins, two proline-rich Gla proteins, two transmembrane Gla ... WebPTHR24040:SF14 GROWTH ARREST-SPECIFIC PROTEIN 6 1 hit; PTHR24040 LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN 1 hit; PRINTS. PR00001 GLABLOOD; …

Gas6 MGI Mouse Gene Detail - MGI:95660 - growth arrest specific 6

WebMar 9, 2024 · The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection. WebHere, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors. foreign and commonwealth uk

GAS6 protein expression summary - The Human Protein Atlas

WebAn Overview for Parents: Growth arrest can occur as a result of trauma, metabolic disorders, malnutrition and underlying skeletal dysplasias. Any disruption or injury to the … WebIn a complete growth arrest, a large enough section of the growth plate has closed and the bone will no longer grow. A limb length discrepancy will then result, the magnitude of … WebApr 24, 2024 · Growth arrest-specific gene 6 (Gas6) is a cytokine that binds to receptor tyrosine kinases Tyro3, Axl, and Mer. Numerous studies have suggested that … foreign and defense policy goals

Growth Arrest Specific Protein 6 - an overview - ScienceDirect

Gas6 ameliorates intestinal mucosal immunosenescence to …

WebGAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant … WebJan 12, 2024 · Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well as platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfunction. Nonetheless, the association between plasma GAS6 levels and acute heart failure (AHF) patients is still unknown. We measured … foreign and domestic diverseyWebFeb 24, 2005 · The growth arrest-specific gene 6 ( Gas-6) is a secreted vitamin K-dependent protein, which binds the receptor tyrosine kinases Axl (also called Ark, Ufo), Sky (also called Rse, Tyro3, Dtk), and C-Mer (also … foreign and domestic auto body

"http://www.informatics.jax.org/marker/MGI:95660 " - Growth arrest specific 6

Growth arrest specific 6

Role of the Gas6/TAM System as a Disease Marker and Potential ... - Hindawi

WebSep 27, 2024 · Excessive endothelial cell stretch causes release of Growth Arrest Specific 6 (GAS6), which activates the tyrosine kinase receptor Axl on monocytes and promotes immune activation and inflammation ... WebDec 2, 2024 · In cancer models and human specimens, specific microenvironmental cues such as transforming growth factor–β2 (TGF-β2) ( 6 ), retinoic acid ( 7 ), bone morphogenetic protein 7 (BMP7), periostin, leukemia inhibitory factor, and growth arrest specific 6 (GAS6) can activate transcriptional programs of quiescence, pluripotency, and …

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WebJan 20, 2024 · Here, we show that growth arrest-specific 6 (Gas6), released by intestinal macrophages that recognize K. pneumoniae , inhibits bacterial invasion into the intestinal epithelium and subsequent translocation to the liver. However, in elderly mice, Gas6 is hardly secreted due to decreased intestinal mucosal macrophages; therefore, K. … WebGrowth arrest-specific gene 6 (Gas6) belongs to the family of vitamin K-dependent coagulation proteins, but in contrast to its other members, has only a limited role in hemostasis. Instead, Gas6 plays a prominent role in conditions of injury, inflammation and repair. Gas6 amplifies the activation of various cell types including endothelial ...

http://www.informatics.jax.org/marker/MGI:95660 WebMar 29, 2024 · Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma. Mikuteit M, Zschäbitz S, Erlmeier M, Autenrieth M, Weichert W, Hartmann A, Steffens S, Erlmeier …

WebGAS6 INFORMATION. Proteini. Full gene name according to HGNC. Growth arrest specific 6. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. GAS6 (AXLLG, AXSF, DKFZp666G247, FLJ34709) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebGrowth Arrest Specific Protein 6 CNS, Pain, Metabolic Syndrome, Cardiovascular, Tissue Fibrosis and Urinary Incontinence. E.A. Meyer, ... ... Besides... New Targets …

WebApr 21, 2024 · In the journal Nature [1], an international research group recently published data on a cellular and molecular mechanism that links stress hormones produced by adrenal glands to the activation of...

WebGas6 (growth arrest-specific gene 6) is the last addition to the family of plasma vitamin K-dependent proteins. Gas6 was cloned and characterized in 1993 and found to be similar to the plasma anticoagulant protein S. foreign and domestic automotiveWebSep 27, 2024 · GAS6 (growth arrest specific 6) exposure promotes the formation of monocyte derived Axl+ Siglec-6+ dendritic cells (AS DCs).A, Human CD14 + monocytes … foreign and domestic carsWebIn this review, we summarize three important emerging VKDPs: Growth arrest‑specific protein 6 (Gas 6), Gla‑rich protein (GRP) and periostin in terms of their functions in physiological and pathological conditions. As examples, carboxylated Gas 6 and GRP effectively protect blood vessels from calcification, Gas 6 protects from acute kidney ... foreign and economic policiesWebIn the present paper, we aimed to review the current evidence regarding the potential role played in fibrogenesis by growth arrest-specific 6 (Gas6) and its receptors Tyro3 protein tyrosine kinase (Tyro3), Axl receptor tyrosine kinase (Axl), and Mer tyrosine kinase protooncogene (MerTK) (TAM). Moreover, we aimed to review data about the ... foreign and five chippewa falls wiWebApr 10, 2024 · Background Uveal melanoma (UM) is the most common intraocular malignancy in adults, with a poor survival prognosis. To date, limited understanding of UM’s molecular mechanisms constitutes an obstacle to developing effective therapy. In this study, we examined key regulators mediating UM progression and their clinical relevance. … foreign and economic policies of japanWebApr 24, 2024 · Growth arrest-specific gene 6 (Gas6) is a cytokine that binds to receptor tyrosine kinases Tyro3, Axl, and Mer. Numerous studies have suggested that macrophage-derived Gas6 interacts with... foreign and domestic restaurant austin txWebGas6 (Growth Arrest Specific 6) is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest (1). foreign and local literature