WebAug 17, 2024 · Overall, 762 JUN/FOS motif occurrences were found on 638 OIS-induced REs. CRISPR library construction and analysis. We designed a CRISPR library to target the FOS/JUN motifs in the OIS-induced REs. For 398 of the 638 OIS-induced REs with the FOS/JUN motif, we found an occurrence of the NGG PAM in a location that is expected … WebAP-1 (activating protein-1) is a collective term referring to dimeric transcription factors composed of Jun, Fos or ATF (activating transcription factor) subunits that bind to a common DNA site, the AP-1-binding site. As the complexity of our knowledge of AP-1 factors has increased, our understanding of their physiological function has decreased.
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WebJan 24, 2024 · A A schematic of the FOS motif in the human USP14 promoter. B The mRNA level of USP14 in FOS-knockdown cells and wild-type cells (n = 3). C The mRNA expression of USP14 induced by TNF-α. WebMay 5, 2024 · Zhang et al. present the cryo-EM structure of ATP-binding cassette transporters ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3.3 Å resolution. This study provides ... WebJan 19, 2024 · Rs34920465 G/A alleles differentially bind to JUN::FOS. a Motif analysis predicted that JUN::FOS motif binds to the G allele of rs34920465. b Luciferase reporter assays using vectors containing the rs34920465 A/G allele in 293T and U-2OS cells. The pGL3-Promoter plasmid (empty) was used as a baseline control. take home salary calculator nj