Eif2a function
eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.
Eif2a function
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WebJan 5, 2024 · Eif2a/Eif4e double mutants showed a severe growth defect, disorganized actin cytoskeleton, and elevated actin levels, suggesting that these factors have a role in cell morphology. Expression of Eif2a downregulated Ure2 internal ribosome entry site (IRES) activity in yeast cells. WebNov 29, 2016 · Although eIF2A was suggested to function as a translation initiation factor as it facilitates loading tRNA i onto the 40S ribosomal subunit via its tRNA i-binding …
WebJan 26, 2013 · A key feature of eIF2α kinase biology is the role of both conserved and unique structural features in the determination of the … WebThe antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human eIF2a that contains serine 52. This region is conserved among many species including rat, pig, cow, fruit fly and yeast. View immunogen . Conjugate: Unconjugated ... Molecular Function: translation initiation factor.
WebNov 18, 2024 · Uncharacteristic of a translation factor, eIF2A resides in the nucleus during normal physiological conditions and is shuttled to the cytoplasm during cell stress. eIF2A knockout mice show... WebMar 29, 2024 · EIF2A eukaryotic translation initiation factor 2A [ (human)] Gene ID: 83939, updated on 29-Mar-2024. Summary. This gene encodes a eukaryotic translation …
WebJun 8, 2024 · Human osteosarcoma U2OS cells stably expressing RFP-LC3 wild type (WT) and knockin for EIF2a S51A (clones 25, 59, and 70, respectively, abbreviated as C25, C59, and C70) were treated with the ...
WebNov 21, 2024 · It is discovered that eIF2A‐KO mice have reduced life span and that eif2A plays an important role in maintenance of lipid homeostasis, the control of glucose tolerance, insulin resistance and also reduces the abundance of B lymphocytes and dendritic cells in the thymic medulla of mice. 4 PDF View 3 excerpts, references methods greenway pet clinic beavertonWebPERK and eIF2a were silenced using siRNA transfection to analyze the regulation of radioresistance by PERK-eIF2a through the NF-jB signaling pathway in oropharyngeal carci-noma cells. In addition, the pathways and mechanisms under-lying this function were investigated to identify new therapeutic targets to increase the radiotherapy efficacy in greenway pharmacy belfastWebJan 29, 2016 · Phosphorylation of eIF2α (eIF2α-P) inhibits exchange of guanosine diphosphate for GTP by eIF2B, the dedicated eIF2 guanine nucleotide exchange factor, which causes inhibition of total protein synthesis ( 8 ). The blockade in translation is important for cell survival and the eventual switch into apoptosis if homeostasis cannot … greenway pest solutions birminghamWebOct 7, 2024 · Eif2a A/S fTg +-Cre + mice were then bred with Eif2a A/A fTg + mice to generate homozygous Eif2a cKI mice and Cre-negative, ... mTORC1 function in hippocampal parvalbumin interneurons: regulation ... greenway pharmacy houstonWebPhosphorylated eIF2a inhibits the function of a guanine nucleotide exchange factor eIF2B, thus downregulates global protein synthesis [7]. Structural features of eIF2a and PKR have pro-vided important insights into the mechanisms by which Ser51 is phosphorylated by eIF2a kinases. The N-terminal half of yeast eIF2a (residues: 1–175) has greenway pharmacy harlowWebThe function of eIF2A in cellular physiology and human disease, has recently attracted substantial atten-tion with the discovery of the eIF2A involvement in the control of antigen presentation by major histocompati-bility complex (MHC) class I molecules,14 the ISR19 and tumor initiation and progression.20 These experiments greenway pharmacy burnhamWebSep 29, 2016 · The yeast Saccharomyces cerevisae eIF2A null mutant revealed no apparent phenotype, however, it was found that in yeast eIF2A functions as a suppressor of internal ribosome entry site (IRES)-mediated translation. It was thus suggested that eIF2A my act by impinging on the expression of specific mRNAs. Subsequent studies in … greenway pest control az