Cross reactivity of carboplatin and cisplatin
WebJan 19, 2024 · The cytotoxic agents that are most commonly associated with infusion reactions are the taxanes, platinum drugs, pegylated liposomal doxorubicin, … WebNausea and vomitingusually occurring within 24 hours of treatment Taste changes Hair loss Weakness Blood test abnormalities: Abnormal magnesium level These are less common (occurring in 10-29%) side effects for patients receiving Carboplatin: Burning sensation at the injection site Abdominal pain Diarrhea Constipation
Cross reactivity of carboplatin and cisplatin
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WebAug 2, 2024 · The rate of carboplatin HSR increases from 1% during the first six cycles to 27% after 7 doses, and the peak rate occurs with cycle 8 or 9, which usually corresponds to the second or third cycle after restarting treatment for recurrent disease [ 10 ]. Similar patterns have been seen with cisplatin and oxaliplatin [ 2, 3 ]. WebAnother study of 31 patients with OCS compared ifosfamide/cisplatin vs. carboplatin/taxol. PFS and OS showed improvement with the use of ifosfamide/cisplatin [ 33 ]. Heinzelmann-Schwarz et al. reported that in endometrial carcinosarcoma platinum/anthracycline or ifosfamide regimens were associated with better outcomes than platinum/taxanes ...
WebJun 3, 2024 · Twenty-one observational studies on cephalosporin cross-reactivity involving 1269 penicillin-allergic patients showed that the risk of cross-reactivity varied with the … WebThere is a low rate of cross-reactivity between cisplatin and other platins such as carboplatin and oxaliplatin. A recent study evaluated 43 patients with histories of …
WebCross-reactivity, in a general sense, is the reactivity of an observed agent which initiates reactions outside the main reaction expected.This has implications for any kind of test … WebOf the wide array of platinum derivatives, carboplatin is the only compound except cisplatin that is used in medical practice, and it differs from cisplatin in the replacement of two chlorine atoms with a cyclobutan-1,1-dicarboxylic acid fragment. Like cisplatin, carboplatin also reacts with DNA to form both internal and external cross-bonds.
WebJul 1, 2024 · This study demonstrates that cross-reactivity between carboplatin and oxaliplatin is very frequent, whereas cross-reactivity between cisplatin and the other …
WebThe platinum 1,3-d(GXG) intrastrand cross-link is one of the adducts formed in the reaction of the antitumor drug cisplatin with DNA, and in fact the major adduct found in cells treated with the cisplatin analogue carboplatin. margaritaville cottages orlando reviewsWebDue to structural differences from cisplatin, it exhibits lower reactivity and slower DNA binding kinetics in vitro. ... 0.907 to 1.216; p = 0.515). 35 In this meta-analysis, a subgroup analysis of the five trials that incorporated cisplatin or carboplatin with a new agent identified a ... The peak levels of DNA cross-linking also occur 6–12 ... margaritaville cottages orlando kissimmee flWebSep 29, 2024 · Cross-reactivity to other platinum-containing drugs can occur; in particular, some reports describe severe HSRs to cisplatin and oxaliplatin in patients with previous allergic reactions to carboplatin, 72, 73 but a recent paper demonstrated a very low cross-reactivity between cisplatin and the other platinum salts. 74 Therefore, if it is not … margaritaville cottages reviewsculligan montpellierWebJun 8, 2024 · Because carboplatin and cisplatin have different toxicity profiles, carboplatin may be effective in patients with platinum-responsive tumors who are unable to tolerate cisplatin because of renal impairment, refractory nausea, hearing impairment, or neuropathy; cisplatin may be preferred in patients with decreased bone marrow reserve … culligan logo imageWebCisplatin was administered instead of carboplatin and was well tolerated by all patients without premedication. CONCLUSIONS: Intradermal skin tests can be used to detect cross-reactivity between platinum agents so that therapy can be continued with a different platinum compound. culligan medallist e2 codeWebOct 14, 2024 · The key difference between carboplatin and cisplatin is that carboplatin shows less consistent survival advantages, whereas cisplatin shows more consistent survival advantages in meta-analyses … culligan lockport il